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AAOS Diagnosis and Prevention of Periprosthetic Joint Infections Clinical Practice Guideline

Keywords: Risk Factors, Injections prior to Arthroplasty, Blood tests for preoperative diagnosis, Serum erythrocyte sedimentation rate (ESR), Serum C-reative protein (CRP), Serum interleukin-6, Peripheral blood leucyte count, Serum tumor necrosis factor-α, Synovial fluid tests, Synovial fluid leukocyte count and neutrophil percentages, Synovial fluid aerobic and anaerobic bacterial cultures, Synovial fluid leukocyte esterase, Synovial fluid alpha-defensin (a-defensin), Synovial fluid nucleic acid amplification testing [e.g., polymerase chain reaction (PCR)] for bacteria, Intraoperative tests Multiple aerobic and anaerobic bacterial periprosthetic tissue cultures, Implant sonication fluid aerobic and anaerobic bacterial cultures, Implant sonication fluid nucleic acid amplification testing (e.g., PCR) for bacteria,18F-FDG PET/CT, 18F-NaF PET/CT, Gram stain, antimicrobials, Antibiotic cement, Preoperative screening and decolonization

Publication Year: 2019

Authors: AAOS (USA)

MeSH Terms:

Diagnosis (E01); Bacterial Infections and Mycoses (C01); Bacteria (B03); Wounds and Injuries (C26); Surgical Procedures; Operative (E04); Musculoskeletal Diseases (C05); Musculoskeletal System (A02)

Publication Scope: prevention, screening, treatment, assessment, management, patient_education

Countries of Application: United States

Guideline Publication Status : Published

Languages : English

Guideline Contact: Barbara Krause (

Publication Date: 03/11/2019

Methods Applied: GRADE, Peer review and Public comment